Adenosine is a neuromodulator with receptor-mediated effects. De novo synthesis of adenosine in brain is low 1; thus, adenosine is primarily derived from dephosphorylation of ATP. In physiological ...
Adenosine formation intracellularly increases with increasing cellular workload and the increase is related to indices such as oxygen consumption 9 and excitatory transmitter release. 10 Adenosine ...