Haemoglobin is a paradigm for exploring allosteric regulation, wherein ligand binding at one site induces conformational changes that affect functional activity at a distant site. These structural ...
Washington, D.C. – A new study, “Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein” published in Biochemistry, provides key insights into how bacterial cAMP receptor ...
In the 50 years since the introduction of "allosteric interactions,” this concept has become one of the pillars of structural, molecular and cell biology, along with the flow of information via the ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...
The shikimate pathway is fundamental for the biosynthesis of aromatic amino acids—tryptophan, tyrosine and phenylalanine—in plants, bacteria and fungi. This pathway, which is absent in mammals, has ...
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