In the kidney, a localized increase of AGT transcription may lead to an increased local AngII production with systemic effects due to the quantitative influence on tubular sodium re-absorption. Indeed ...

Patients with sickle cell anemia (SCA) and persistent albuminuria (PA) exhibited significantly higher levels of urinary angiotensinogen (AGT). “What we’re most excited about is that urinary ...

The renin–angiotensin–aldosterone system (RAA system) contributes to blood pressure (BP) regulation by influencing vascular tone and water–sodium reabsorption. The physiological significance of this ...

Association between treatment facility volume and mortality in patients with glioblastoma (GBM): A large national analysis. This is an ASCO Meeting Abstract from the 2018 ASCO Annual Meeting I. This ...

We were unable to process your request. Please try again later. If you continue to have this issue please contact [email protected]. Zilebesiran lowered serum angiotensinogen levels and ...

We have identified human cultured cell lines that are useful for studying angiotensinogen gene expression and its regulation in the central nervous system. A model cell system of human central nervous ...

The drug, which interferes with RNA to reduce production of angiotensinogen, could make it possible to treat hypertension with quarterly or twice yearly subcutaneous administration. Zilebesiran, an ...

In this first-in-human, placebo-controlled study, patients who received zilebesiran showed dose-dependent decreases in serum angiotensinogen levels and 24-hour ambulatory BP after a single ...

Researchers said these findings confirm that zilebesiran can significantly reduce serum angiotensinogen levels, leading to sustained reductions in blood pressure over a 24-hour period, even 6 months ...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today that it is broadening its pipeline with ALN-AGT, a subcutaneously ...