LaBonne is president of the Society for Developmental Biology and the Erastus Otis Haven professor of molecular biosciences at Northwestern University. Imagine a world without lifesaving medicines, ...

In recent months, the Food and Drug Administration and National Institutes of Health have announced new initiatives to reduce and replace animal testing in biomedical research. Central to these ...

Due to advancements in genetic engineering, small animal models are continuing to change in response to market needs. Model developers strive to better reflect the role of this important asset in both ...

CRISPR-Cas9 technology is used to knock out or modify DNA in research mice to study disease phenotypes and develop new treatments. CRISPR mice and rats are offered by Charles River, which uses genetic ...

Visit NAP.edu/10766 to get more information about this book, to buy it in print, or to download it as a free PDF. 1 As discussed in Chapter 2, current animal models do not adequately reflect the human ...