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Back mutations, restoring critical non-human residues to retain binding affinity. Computational modeling and in silico tools to predict stability, reduce immunogenic epitopes, and optimize sequences.

Antibodies play a vital role in the immune system by providing protection against foreign invaders, such as bacteria and viruses. Produced by B cells, antibodies are protein molecules that can be ...

Integral Molecular Uses Shotgun Mutagenesis to Germline-Humanize Monoclonal Antibodies Seventy percent of FDA-approved monoclonal antibodies (mAbs) and approximately 66% of mAbs currently in clinical ...

A research group have succeeded in humanization of mouse antibodies that can neutralize the infection caused by human herpesvirus 6B. The team created ''humanized'' antibodies based on mouse ...

An international research consortium, led by scientists at VIB and UGent, has developed a new platform that could change how ...

BELFAST, Northern Ireland--(BUSINESS WIRE)--Fusion Antibodies plc, experts in antibody engineering and Analytics Engines, an advanced data analytics company, have announced a strategic collaboration ...

Antibody engineering and production are essential tools in drug discovery, providing powerful and specific therapeutics and diagnostic/prognostic materials for various diseases. Antibodies are ...

The "Antibody Humanization and Affinity Maturation: Services and Platforms, 2017-2030" report has been added to Research and Markets' offering. The "Antibody Humanization and Affinity Maturation: ...

Antibody humanization and affinity maturation have revolutionized the biotech industry in the past 10–20 years, enabling the development of highly effective therapeutic antibodies that can be used to ...