Mass Spec Alternative Detects Biomarker Signatures in Tissues, Blood, and Cell Culture The current generation of antibody microarray technologies is providing highly sensitive new tools for screening ...

Protein microarrays are one aspect of highly automated, large-scale biological screening technologies, the other is nucleic acid arrays. As DNA arrays reveal their origin in Southern blotting ...

A phase I/II study of αGalactosylceramide-pulsed dendritic cells in patients with advanced or recurrent non-small cell lung cancer No significant financial relationships to disclose. This is an ASCO ...

As illustrated by Dr. Carl Borrebaeck, [4] of Lund University, Sweden, bioarrays may be based on proteins or on affinity reagents. Defined sets of proteins, such as autoantigens, are spotted on ...

Microsatellite instability (MSI) and loss of heterozigocity (LOH) in the peripheral blood mononuclear cells (PBMC) of breast cancer (BC) patients receiving systemic chemotherapy ...

When it comes to enzymes, protein abundance does not necessarily translate into protein activity: Post-translational modifications such as phosphorylation can dramatically alter enzyme function.

Proteomics has become an essential area in medical research, propelled by the ability to quantitatively assess proteins on a large scale using high-throughput technologies. These technologies have ...

In a new application for CRISPR/Cas editing tools, researchers at Harvard Medical School, Boston, Massachusetts, have created a CRISPR/Cas9 ribonucleoprotein-based peptide display approach. This ...

If there's anyone who can appreciate tissue microarrays, it's histology technician Sabina Magedson. Having worked in a pathology laboratory at M.D. Anderson Cancer Center in Houston for years, ...

Tissue microarrays combines tens to hundreds of paraffin-embedded tissue cores into a single paraffin block. It is a practical and highly effective technique for high-throughput analyses of various ...