Fred Hutch researchers invent a CRISPR screening method to understand RNA-binding proteins often mutated in cancer and other diseases In biology’s standard tale of two acids — deoxyribonucleic (DNA) ...

In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That’s where Perturb-Seq comes in—a method ...

CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR RNA-guided cleavage. Type V CRISPR-Cas (Cas12) systems, in particular, ...

In recent years, the scientific community has made significant strides in the field of gene editing, particularly through the development of the CRISPR (Clustered Regularly Interspaced Short ...

CRISPR-Cas9 enables researchers to make precise and targeted edits in the genome to determine gene function. For this, scientists use guide RNAs, which are short stretches of RNA sequences that lead ...

CRISPR has revolutionized science. AI is now taking the gene editor to the next level. Despite its real-world impact, CRISPR isn’t perfect. The tool snips both strands of DNA, which can cause ...