Complete disruption of the CXCR4 chemokine receptor gene is embryologically lethal in mice, 11, 12 impeding direct study of CXCR4-mediated tumor progression and metastasis. Current approaches to study ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

An evaluation of the role of Src in renal cancer. Background: CXCR4, a chemokine receptor, is implicated in the metastastic process. Higher expression of CXCR4 in renal cell carcinoma predicts shorter ...

Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases. A natural fragment of serum albumin, named EPI-X4, has previously been ...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--X4 Pharmaceuticals today announced the launch of the company’s development strategy for its pipeline of C-X-C receptor type 4 (CXCR4 inhibitors), including two ...

Phase I clinical trials evaluating olaparib in combination with radiotherapy (RT) and/or temozolomide (TMZ) in glioblastoma patients: Results of OPARATIC and PARADIGM phase I and early results of ...

Dr. Susan Schwab and her lab at the NYU Langone Medical Center have associated CXCR4 signaling as a positive regulator of T-cell acute lymphoblastic leukemia (T-ALL) growth and disease progression.

BERLIN, DE / ACCESS Newswire / October 6, 2025 / Pentixapharm Holding AG (Frankfurt Prime Standard:PTP), an advanced clinical-stage biotech developing novel radiopharmaceuticals, today announced the ...

Even with modern 3D conformal treatments skin radiation injury can be an inadvertent complication associated with clinical radiotherapy particularly at tissue folds. It is also of concern in the ...

ALX40-4C NPS Allelix Terminated (Phase I/II) HIV No apparent effect was observed on viral load AMD3100 AnorMED Terminated (Phase I/II) HIV Little effect was observed on viral load AMD3100 (plerixafor) ...