It achieves AI-driven generative design of the first permeable macrocyclic peptide with more than two polar or ionizable fragments. -- Surrogate assays are a breakthrough for AI model training. 1910 ...

For more than a century, oral insulin has been considered a "dream" therapy for diabetes, hindered by enzymatic degradation ...

Copper peptides stand out among these other peptides because they can do the work of multiple peptides in one. Copper ...

To understand the focus of startup Insamo Inc., one need look no further than its name, which co-founder and CEO Timothy Craven described as “portmanteau of ‘internally satisfied molecules,’” ...

For more than a century, oral insulin has been considered a "dream" therapy for diabetes, hindered by enzymatic degradation in the digestive tract and the absence of a dedicated intestinal transport ...

Receive the the latest news, research, and presentations from major meetings right to your inbox. TCTMD ® is produced by the Cardiovascular Research Foundation ® (CRF). CRF ® is committed to igniting ...

An illustration shows how custom-made peptide molecules (shown in pink and purple) can slip through a cell membrane. (Image by Ian C. Haydon / UW Institute for Protein Design) Researchers at the ...

The Tat-SIRT5-CTM peptide specifically blocked the interaction of SIRT5 with ANXA1, led to SIRT5 degradation and thereby inhibiting SIRT5-mediated desuccinylation of ANXA1, which in turn alleviated ...

Insamo Inc., founded in 2022 to combine machine-learning capabilities, high-throughput screening and genetic engineering to create orally administered membrane-permeable cyclic peptides across a range ...