Centromeres are curious structures. These specially organized chromosomal regions are best known for their unique and critical role in cell division, in which they are well understood to serve as the ...

Despite the immense amount of genetic material present in each cell, around 3 billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities. The ...

A research team at The University of Osaka has found a novel pathway for depositing CENP-A into vertebrate centromeres, which ...

Despite the immense amount of genetic material present in each cell, around three billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities.

Researchers from the Kops group in collaboration with researchers from the University of Edinburgh, made a surprising new discovery in the structure of the centromere, a structure that is involved in ...

Super-resolution microscopy image of a mitotic chromosome (white) with the centromeres of each sister chromatid depicted in orange. Each centromere consists of two distinct chromatin subdomains ...

A genomic study of human and selected nonhuman primate centromeres has revealed their unimaginable diversity and speed of evolutionary change. Although centromeres are vital to proper cell replication ...

Researchers propose a two-step regulatory mechanism for non-Rabl configurations of centromeres in the nucleus. Centromeres are chromosomal domains that link pairs of sister chromatids together during ...

In cells, CENP-A binds to histone H4 and HJURP before it is incorporated into the centromere. The previous model proposed that HJURP recognizes Mis18C and CENP-A is incorporated into the centromere ...