Centrosomes are small structures in cells with many essential functions, including roles in cell signaling and in organizing a cell’s cytoskeleton. Centrosome dysfunction contributes to diseases like ...

The cover for issue 26 of Oncotarget features Figure 6, "Mislocalization of IQGAP1-BRCA1 in human TNBC tumors phenocopies the dominant mutants and the TNBC cells," by Osman, et al. and reported that ...

The centrosome is the major microtubule-organizing centre (MTOC) in eukaryotic cells, being comprised of two centrioles surrounded by an electron-dense matrix, the pericentriolar material (PCM). The ...

The centrosome has been a subject of fascination for cell biologists for at least a century. It is at the centre of the cell and is the structure on which microtubules organize themselves both during ...

A recent Cell Reports paper by the Oxenius group (IMB) demonstrates a function of targeted centrosome inheritance during CD8+ T cell division for the generation of memory precursor cells.

This is a preview. Log in through your library . Abstract The centrosome functions as the major microtubule-organizing center and plays a vital role in guiding chromosome segregation during mitosis.