Cystine stones are a type of kidney stone. They are also called renal calculi, nephrolithiasis, or urolithiasis, and they are caused by a genetic condition. Here’s what to know about cystine crystals ...

CYSTINE-STORAGE disease (cystinosis or Lignac-> Fanconi disease) is an uncommon but intriguing disorder, the etiology and pathogenesis of which are unknown. The cardinal pathological finding is the ...

Fibroblasts derived from patients with cystinosis, an autosomal recessive condition, accumulate the disulfide amino acid cystine within lysosomes. The metabolic defect leading to the cystine ...

Using molecules that closely mimic the structure of the dimeric amino acid L-cystine, chemists have discovered a way to suppress formation of large L-cystine crystals. The finding, reported in Science ...

The ability of cystine dimethylester (CDME) to load lysosomes with cystine has been used to establish the basic defect in cystinosis: defective cystine exodus from lysosomes. Using CDME loading, it ...

CYSTARAN (cysteamine) 0.44% ophthalmic solution Cystaran (cysteamine ophthalmic solution; Sigma-Tau) is the first FDA-approved therapy for the treatment of corneal cystine crystal accumulation in ...

Cystinuria is an inherited health condition that involves the excretion of excess cystine and other dibasic amino acids in the urine. Although cystinuria itself doesn’t cause noticeable symptoms, the ...

Use of DPC-4 immunostaining of diagnostic cytology specimens to predict the pattern of tumor progression in locally advanced pancreatic cancer patients (LAPC). Background: The plasma membrane xCT ...

Cystinuria occurs in one out of every 7,000 in the world, but its curative treatment has not been established. AGT1/SLC7A13, a protein, is an unknown factor that binds with the protein rBAT/SLC3A2, of ...

RECENTLY, Koyanagi and Odagiri 1 reported that the cystine content of skin of rats dosed with a small quantity of vitamin A is lower than that of rats given a liberal allowance of the vitamin. In the ...

Peptides as therapeutics are advantageous since they are generally safe and well tolerated, with a short half-life limiting risk for off-target toxicities. However, because of their small size, most ...

Cystine lyase degrades L-cystine by a β-elimination to form cysteine persulfide, pyruvate, and ammonia. This enzyme is common in Brassica sp. and has been purified to homogeneity from extracts of ...