Directed evolution is an effective strategy to optimize the properties of proteins for specific requirements, either for industrial, therapeutics or research applications. As the theoretical diversity ...

Recent trends in directed enzyme evolution focus on combining high-throughput screening methods with advanced biophysical tools and data-driven computational approaches. However, these methods pose ...

A research team maps the key tasks that define modern enzyme engineering—function annotation, structure modeling, and property prediction—and explain how AI methods now accelerate each step, from ...

Researchers from the Manchester Institute of Biotechnology (MIB) have developed a new enzyme engineering platform to improve plastic degrading enzymes through directed evolution. To illustrate the ...

Directed evolution—a process in which a protein library is subjected to repeated rounds of mutation and selection to achieve desired properties—can improve the catalytic performance of computationally ...

Among the hypotheses for how viruses came to be is that they started as self-replicating nucleic acids that co-opted host proteins for packaging and protection, leading eventually to the viral ...

Researchers have shown how laboratory evolution can give rise to highly efficient enzymes for new-to-nature reactions, opening the door for novel and more environmentally friendly ways to make drugs ...

Enzymes catalyze chemical reactions in organisms - without which life would not be possible. Leveraging AlphaFold2 artificial intelligence, researchers at Charité – Universitätsmedizin Berlin have now ...

In nature, evolution takes years to sculpt new traits. In the lab, scientists hope to achieve this feat much faster: Being able to evolve proteins with enhanced or novel functions has important ...

The results revealed a clear sequence. Enzymes predating cannabis showed no ability to process CBGA. The first enzyme unique ...