Researchers have developed a new enzyme engineering platform to improve plastic degrading enzymes through directed evolution. Researchers from the Manchester Institute of Biotechnology (MIB) have ...

Directed evolution—a process in which a protein library is subjected to repeated rounds of mutation and selection to achieve desired properties—can improve the catalytic performance of computationally ...

Using computational design and directed evolution, scientists have successfully created a metalloprotein that can catalyze a commonly used organic reaction more efficiently than any known enzyme (Nat.

Chemists created an enzyme with boronic acid at its reactive center. This approach can produce more selective reactions with boron, and allows the use of directed evolution to improve its catalytic ...

A research team maps the key tasks that define modern enzyme engineering—function annotation, structure modeling, and property prediction—and explain how AI methods now accelerate each step, from ...

Researchers at MIT have made a major breakthrough in optimizing rubisco, a key enzyme in photosynthesis. By modifying a bacterial version of this molecule, they achieved a 25% higher catalytic ...

Scientists have developed a novel approach to modifying enzymes to improve functionality. They designed a new algorithm to make multiple changes to an enzyme sequence at once as compared to the ...

The rational design of enzymes is an important goal for both fundamental and practical reasons. Here, we describe a process to learn the constraints for specifying proteins purely from evolutionary ...

Enzymes catalyze chemical reactions in organisms—without which life would not be possible. Leveraging AlphaFold2 artificial intelligence, researchers at Charité—Universitätsmedizin Berlin have now ...