The protein periostin may promote the spread of pancreatic cancer—and pain—through nerves

A new Brazilian study has revealed the key role of the protein periostin and stellate pancreatic cells in allowing pancreatic ...
BioWorld

Insights into extracellular matrix are metastasis map

New research has uncovered a complex interplay between extracellular matrix (ECM) structure and the transcriptional responses of cancer cells, showing how they alter their gene expression to ‘escape’ ...
PharmiWeb

Engitix Announces $25 Million Series A Extension Financing by Existing Investor Mike Platt to Advance ECM-Targeted Therapeutics in Solid Tumors and Fibrosis

Engitix Announces $25 Million Series A Extension Financing by Existing Investor Mike Platt to Advance ECM-Targeted ...
EurekAlert!

Study reveals protein linked to spread of pancreatic cancer through nerves

Brazilian research shows that stellate pancreatic cells produce periostin, remodeling tissue and facilitating tumor infiltration, a key mechanism of the aggressiveness and high mortality of the ...
The Pharma Letter

Engitix adds $25m to fuel ECM-driven push in cancer and fibrosis

UK biotech Engitix has raised a $25 million series A extension from existing investor Netherton Investments, investing on behalf of BlueCrest Capital Management co-founder Mike Platt. The funding will ...
mskcc.org

Into the Matrix: MSK’s Mara Sherman is Unlocking the Secrets of the Fibrotic Fortress that Surrounds and Protects Pancreatic Cancer

These fiber-producing cells, or fibroblasts, make collagen and the extracellular matrix that gives shape and structure to our tissues. Fibroblasts can be found in many solid tumors, but they are ...
Frontiers

Extracellular Vesicles as Mediators and Biomarkers in Aging and Neurodegenerative Disorders: From Molecular Cargo to Clinical Translation

Extracellular vesicles (EVs), including exosomes, microvesicles, apoptotic bodies, and many other EV subtypes, have emerged ...