There is no specific “diagnostic” or pathognomonic laboratory marker for ankylosing spondylitis/axial spondyloarthritis (AS/axSpA), and diagnosis is based on clinical history, physical examination and ...

The HLA-B27 genetic marker is known to be associated with increased risk for various arthropathies, including JIA. Whether the genetic marker's presence has prognostic value has been uncertain. In ...

In patients with spondyloarthritis, onset of common musculoskeletal symptoms such as back pain led to diagnostic delays averaging over 7 years. Onset with extra-musculoskeletal manifestations such as ...

A 14-year-old Japanese boy noted a blurred vision for 3 weeks in the left eye and was referred to our clinic on 1 February 2001. His best-corrected visual acuity (BCVA) was 6/6 in the right eye and ...

HLA testing has been a staple in transplantation since the recognition that antibodies, directed against lymphocytes, were associated with allograft failure. This seminal finding led to the discovery ...

Human leukocyte antigen (HLA) typing is important in organ transplantation protocols, as they determine the likelihood of rejection. The HLA system is little understood, however. In simple terms, the ...