Human haploid ESCs exhibited typical colony morphology and expressed classical human ESC markers, including alkaline phosphatase, OCT4, NANOG, SSEA4, SOX2, TRA-1-81 and TRA-1-60 (Figure 1E and ...

The study, titled Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions, was published on October 11 in the journal Cell Stem Cell. The ...

Since the emergence of molecular genetics more than fifty years ago, scientists have tried to isolate haploid mammalian cells, that is, cells with half the number of chromosomes contained in somatic ...

“In diploid cells, mutating just one copy of a gene usually does not produce a biological effect because there is always a second copy that serves [as] a ‘backup,’” study coauthor Ido Sagi of Hebrew ...

Stem cell research holds huge potential for medicine and human health. In particular, human embryonic stem cells (ESCs), with their ability to turn into any cell in the human body, are essential to ...

Haploid plants, which carry only a single set of chromosomes, are typically sterile, making them valuable but difficult to use in breeding. A rare peach haploid mutant, '9-D', surprisingly exhibited ...

A common strategy to create high-yielding plants is hybrid breeding. However, getting the inbred lines in the first place can be a hassle. In maize, the use of so-called 'haploid inducers' provides a ...

An agronomist has launched a Doubled Haploid Facility that can develop pure, inbred corn lines in less time than traditional methods. Agronomists at Iowa State University are offering doubled haploid ...

Sometimes less is more. Scientists have created a new kind of human stem cell that has just half a genome. The cells can be turned into any tissue in the human body, despite only containing one set of ...

Researchers have created mouse embryonic stem cells that contain only one set of chromosomes, rather than two, according to a study publishing today (September 7) in Nature. The new cells could be ...