Patients with Parkinson's disease suffer a specific loss of dopaminergic neurons from the midbrain region that controls motor function. The exact mechanism of this selective neurodegeneration is ...

Microtubules are dynamic, tubular polymers composed of αβ-tubulin dimers that form an essential framework within eukaryotic cells. They orchestrate a wide range of cellular functions including ...

Microtubules -- cellular "highways" that deliver cargo to the cell membrane for secretion -- have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin ...

This is a preview. Log in through your library . Abstract γ-Tubulin is a conserved component of microtubule-organizing centers and is thought to be involved in microtubule nucleation. A recently ...

Microtubules are cell constituents that display several astounding properties and a unique pattern of behavior during the cell cycle. Microtubules are regulated by several proteins and complexes, and ...

Certain chemotherapy drugs, including paclitaxel (Taxol), block cancer cell division by targeting microtubules—structural polymers that are critical for cell division and other functions. Such ...

This is a preview. Log in through your library . Abstract We used the inhibitor nocodazole in conjunction with immunofluorescence and electron microscopy to investigate microtubule function in the ...

The protein NEK7 regulates neuron formation, as it is required for dendrite growth and branching, as well as the formation and shaping of dendritic spines. The protein NEK7 regulates neuron formation, ...

Microtubules, a key component of the cytoskeleton in eukaryotic cells, serve as scaffolds and play vital roles in cellular processes such as cell division, cell migration, intracellular transport, and ...

Zachary Gergely, Ammon Crapo, Loren Hough, J. Richard McIntosh, and Meredith D. Betterton (2016). Molecular Biology of the Cell27, 3490. arXiv DOI: 1604.08134. DOI ...

The protein NEK7 regulates neuron formation, as it is required for dendrite growth and branching, as well as the formation and shaping of dendritic spines. These are the main conclusions of a study ...