A new discovery may explain why so many people abandon cholesterol-lowering statins because of muscle pain and weakness.

For decades, statins have been the quiet workhorses of cardiology, cutting heart attack and stroke risk for millions while leaving a stubborn puzzle unsolved: why do some patients feel their muscles ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these ...