A new study reveals a critical vulnerability in a brain receptor targeted by a rare autoimmune disease. Researchers have ...

New OHSU study maps antibody "hot spots" behind anti‑NMDAR encephalitis. Could change diagnosis and treatment.

Some serious brain disorders begin with symptoms that are easy to misinterpret. A person may become confused, forgetful or ...

Scientists have identified a promising target for treatment of a devastating autoimmune disease affecting the brain.

The images showed that nearly all the antibodies bind to a single domain of the receptor, providing a viable target for novel therapeutics.

A new study suggests a potential molecular strategy for treating fragile X syndrome, an inherited neurodevelopmental disorder that causes autism spectrum disorder and intellectual disability. This ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...

The links between neurons are crucial to the brain, and brain cells can reorganize the way they are linked together in a phenomenon known as neuroplasticity. This process is ongoing during a lifetime, ...

D epression can be challenging to treat. Typical antidepressants, which affect levels of chemicals in the brain involved in mood regulation, have been evolving for decades. But recent findings ...

Three distinct snapshots obtained with cryo-electron microscopy illustrate the arrangement of two of the four symmetrical subunits that make a functional NMDA receptor. During activation, as the ...