Histone Kla regulates tumor angiogenesis by affecting the levels of downstream HIF1-ɑ and Vegf. In non-histone proteins, YY1-Kla influences FGF2, and Sema3A-Kla affects HIF1-ɑ, both contributing to ...

In this paper, we comprehensively review the role of non-histone protein lactylation in cerebral ischemia–reperfusion (I/R) injury from multiple perspectives, including its dynamic alterations during ...

A study on the posttranslational modification through lactylation of non-histone proteins revealed a mechanism that participates in genome stability and provides resistance to chemotherapy. Scientists ...

Researchers from the Alzheimer's Center at Temple (ACT) provide new insights into how microglia, the brain's immune cells, exhibit an apparent dual function with the ability to both increase and ...

In a groundbreaking advancement for cancer treatment, a research team led by Professor Xiang David Li from the Department of Chemistry at The University of Hong Kong (HKU) has made significant strides ...

Protein misfolding and mislocalization are common themes in neurodegenerative disorders, including motor neuron disease, and amyotrophic lateral sclerosis (ALS). Maintaining proteostasis is a ...

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease. This process, driven by the enzyme ...