Mass spectrometry has evolved into a cornerstone of structural proteomics, offering rapid, sensitive and site-specific insights into protein architecture, interactions and dynamics. By coupling ...

Proteins in cells are highly flexible and often exist in multiple conformations, each with unique abilities to bind ligands. These conformations are regulated by the organism to control protein ...

Caltech scientists have developed a method driven by machine learning that allows them to accurately measure the mass of individual particles and molecules using complex nanoscale devices. The new ...

This episode of the Pharmaron DMPK Insights Podcast Series features Scott Summerfield (Executive Director of Metabolism at Pharmaron) and John Mehl (consultant and previous director at GSK, and ...

Researchers created a DIA-MS atlas of 13,609 proteins across 2,856 samples from fetal, healthy adult, paired non-tumor, and ...

As instruments grow faster, leaders say clinical impact will depend on trust, standards, data, and assays built for real ...

Researchers at the Purdue Institute for Cancer Research (PICR) have developed a next-generation technology platform designed ...

This article explores how new technologies in plasma proteomics enable the simultaneous analysis of thousands of proteins, ...

MALDI remains a powerful tool for analyzing large biomolecules with minimal fragmentation. In this process, peptides or proteins are co-crystallized with a matrix on a metal plate. A laser pulse ...

Those hoping to uncover new science may feel disheartened if they struggle with inadequate tools and doubt that more capable tools are within reach. Until recently, such was the case in proteomics.

A new data-driven technique, called fingerprint mass spectrometry, provides a method for measuring the mass of individual proteins using nanoscale devices. Caltech scientists have developed a method ...