Zimislecel is an allogeneic stem cell-derived islet cell therapy that could eliminate the need for insulin in those who have ...

As people age, their immune system function declines. T cell populations become smaller and can't react to pathogens as ...

Jonas Salk quietly built the polio vaccine through rigorous, methodical work in Pittsburgh: treating patients, refinin ...

What if your liver was silently preparing for cancer — just six months after starting a high-fat diet? New research from MIT ...

The capacity of an organism to regenerate depends on cell dedifferentiation followed by proliferation. Mammals, in general, have limited regenerative capacity. Now, a team of researchers at the Salk ...

Atomic defects in nanodiamonds enable both precise heating of lysosomes inside macrophages and nanoscale temperature ...

It is well known that adding a mixture of four reprogramming molecules (Oct4, Sox2, Klf4 and c-Myc) also known as “Yamanaka factors” to cells can reset epigenetic marks to their original patterns.

A mechanism underlying neutrophil reprogramming in brain cancers has been uncovered, illuminating potential therapeutic targets to stop their pro-cancer effect. Tumor-infiltrating neutrophils are ...

Cells of a multicellular organism are functionally heterogeneous owing to the differential expression of genes. Historically, differential gene expression had been thought to involve the genetic ...

Induced pluripotent stem (iPS) cells hold the potential to revolutionize regenerative medicine through their capacity to generate cells of diverse lineages for future patient-specific cell-based ...

Researchers have identified key factors that promote the reprogramming of human stem cells to the naïve state, which can be used to model the earliest stages of development. This new knowledge will ...