IL-21 is a type I cytokine essential for immune cell differentiation and function. Although IL-21 can activate several STAT family transcription factors, previous studies focused mainly on the role of ...

In other subtypes of glioblastomas, Stat3 functions as a tumor suppressor gene. In the tissue samples above, the cancer has lost the tumor-suppressor PTEN, leaving that function almost entirely up to ...

BOSTON, Mass. (February 6, 2008)—Perhaps the only positive spin one can put on the brain cancer glioblastoma is that it’s relatively uncommon. Other than that, the news is bad. It is nearly always ...

March 25, 2013--TAMPA, Fla. – Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have developed a small molecule that inhibits STAT3, a protein that causes cancer.

VVD-130850 is an investigational oral small molecule inhibitor of STAT3 transcription factor developed for treatment of advanced solid and hematologic tumors as a single agent and in combination with ...