Cells organize their molecules into distinct functional areas. While textbooks usually refer to membrane-bound organelles ...

These include stress granules and proteasome storage granules (PSGs). In the past, these membraneless organelles were only visible as “droplets” using a fluorescence microscope. Now, researchers from ...

Targeted protein degradation (TPD) approaches including PROTAC and molecular glue have revolutionized drug discovery. However, in part due to complication of the ubiquitination and related ...

Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease ...

Much like humans generate mountains of garbage, our cells are constantly discarding proteins that are damaged or no longer needed. The cellular waste disposal system called the proteasome is best ...

Developing small molecules that activate a subset of the body’s proteasomes to degrade defective proteins could be an effective way to treat neurodegenerative diseases and other complex disorders ...